"After a radiation explosion caused four mechanical arms to fuse yo his body, nuclear physicist Otto Octavius turned to a life of crime to prove his genius to the world. Telepathically operating the arms with lethal acuity, "Doc Ock's" egomania is rivaled only by his spite for the wall-crawling Spider-Man".
Organisations: Sinister Syndicate
- Mission 1 - Armed & Dangerous (Normal, Hard, and Heroic)
- Mission 6 - The Sinister Serum (Normal, Hard and Heroic)
Note: These are his stats at Level 9
|Super Villain||Takes turns faster|
|Criminal Mastermind||Doctor Octopus's allies deal +20% damage. Doctor Octopus takes +20% damage.|
|Tenticle Whip - Single-Target Attack||Applies Crushed to target|
|______ Venom - Single-Target Attack||Applies Wounded to target|
"Having eight limbs grants Doctor Octopus ample oppurtunities for counterattacks. As he analyzes the fight with his genius intellect, his Accuracy increases and his strikes do more and more damage".
- Doctor Octopus can be found during the Level 10 Scouting Mission when facing Sinister Syndicate grunts.